BIOLOGICAL, BIOINSPIRED AND BIOMATERIALS
Welcome to the multidisciplinary research group B3Mat (Biological, Bioinspired and Biomaterials) of the Adolfo Ibáñez University, located in the city of Viña del Mar, Chile.
Our objective is to develop strategies to value the use of natural and artificial biomaterials for potential biotechnological and biomedical applications. For that we have established a multiscale and integrative technological platform of experimental biomechanical models, in vitro biological models and computational models.
At B3mat we firmly believe that science is a social and collaborative activity, so our work not only seeks to conduct high-level research, but also to help it reach citizens.
We are a research group committed to both inclusion and the environment as well as education and transfer of scientific knowledge to our community.
The members of our research group come from various branches of science and engineering, forming a multidisciplinary team. In addition, they train undergraduate and postgraduate students, both at the Adolfo Ibáñez University and others nationwide. They also actively collaborate with researchers from Chile and abroad.
FACULTY AND FELLOWS
STUDENTS AND COLLABORATORS
1. Vallejos Baier, R., Contreras, J., Toro, C., Bustamante, M., Pérez, L., Burda, I., Aiyangar, A., & Vivanco, JF "Structure-function assessment of 3D-printed porous scaffolds by a low-cost / open source fused filament fabrication printer ". Materials Science and Engineering C: Materials for Biological Applications. 2021
2. Benjumeda W., Vallejos R., Santibanez J., Millán C., Vivanco JF “Analysis of cell-biomaterial interaction through cellular bridge formation in the interface between hGMSCs and CaP bioceramics” Scientific Reports. 2020.
3. García R., Poupin M., Urrutia C., Rodríguez A., Grenier C., Vivanco JF, Ramajo L., Benjumeda I., Lagos N., Lardies M. "An intrapopulational study of the Antarctic bivalve Laternula elliptica (PP King, 1832) at King George Island with emphasis on organic components and biochemical properties of the shell "(submitted). 2020.
Four. Norambuena-Contreras J., Arteaga-Perez L., Guadarrama-Lezama A., Briones R., Vivanco JF, Gonzalez-Torre I. “Microencapsulated Bio-Based Rejuvenators for the Self-Healing of Bituminous Materials” Materials. 2020.
5. Vallejos R., Irribarra V., Benjumeda-Wijnhoven I., Millán C., Vivanco JF “Microporosity Clustering Assessment in Calcium Phosphate Bioceramic Particles”. Frontiers in Bioengineering and Biotechnology. 2019.
6. Vukasovic T., García C., Vivanco JF, Celentano D. “Characterization of the Mechanical response of thermoplastic parts fabricated with 3D printing” The International Journal of Advanced Manufacturing Technology. 2019.
7. Millán C., Vivanco JF, Benjumeda-Wijnhoven IM, Bjelica S., Santibáñez JF “Mesenchymal Stem Cells and Calcium Phosphate Bioceramics: Implications in Periodontal Bone Regeneration”. Chapter from book: Advances in Experimental Medicine and Biology. Springer, New York, NY. 2018.
8. Ruggeri F., Leiva V., Saulo H., Vivanco JF, “A Methodology Based on the Birnbaum-Saunders Distribution for Reliability Analysis Applied to Nano-materials”. Reliability Engineering & System Safety. 2017.
9. Vivanco JF, Aiyangar A., Slane J., “Multiscale Biomechanical Characterization of Bioceramic Bone Scaffolds. Chapter from Book: Experimental Methods in Orthopedic Biomechanics. 2017.
10. Slane J., Vivanco JF, Squire M., Ploeg HL, "Characterization of the Quasi-Static and Viscoelastic Properties of Orthopedic Bone Cement at the Macro and Nanoscale." Journal of Biomedical Materials Research: Part B Applied Biomaterials. 2016.
11. Norambuena-Contreras J., Gonzalez-Torre I., Vivanco JF, Gacitúa W., “Nanomechanical Properties of Polymeric Fibers Used in Geosynthetics Composites”. Polymer Testing. 2016.
12. Burgers T., Vivanco JF, Bart W., "Mice with a Heterozygous Lrp6 Deletion Have Impaired Fracture Healing." Bone Research. 2016.
13. Meyer L, Johnson M., Cullen D., Vivanco JF, Blank R., Smith E., Ploeg HL "Combine Exposure to Big Endothelin-1 and Mechanical Loading in Bovine Sternal Cores Promotes Osteogenesis". Bone. 2016.
14. Marchant C., Leiva V., Cysneiros F., Vivanco JF, "Multivariate Birnbaum-Saunders Regression Models: Diagnostic Analysis and Application" Journal of Applied Statistics. 2016.
fifteen. Leiva V., Vivanco JF, “Fatigue Models”. Wiley StatsRef: Statistics Reference Online. 2015.
16. Collins C., Vivanco JF, Burgers T., Ploeg HL "Fracture Healing in Mice Lacking Pten in Osteoblasts: A Micro-Computed Tomography Image-Based Analysis of the Mechanical Properties of the Femur." Journal of Biomechanics. 48 (2): 310-317. 2015.
17. Slane J., Vivanco JF, Squire M., Ploeg HL "Mechanical, Material, and Antimicrobial Properties of Acrylic Bone Cement Impregnated with Silver Nanoparticles" Materials Science and Engineering C: Materials for Biological Applications. 48: 188-196. 2015.
18. Vivanco J., Burgers T., García S., Ploeg HL “Estimating the Density of Human Trabecular Bone Using Clinical CT Scan Data”. Journal of Engineering in Medicine. 228: 616-626. 2014.
19. Vivanco J., Jakes J., Slane J., Ploeg HL "Accounting for Structural Compliance in Nanoindentation Measurements of Bioceramic Bone Scaffolds". Journal of Ceramics International. 2014.
20. Slane J., Vivanco J., Ploeg HL, Squire M. "The Influence of Low Concentration a Water Soluble Porogen on the Material Properties, Antibiotic Release, and Biofilm Inhibition of an Acrylic Bone Cement." Materials Science and Engineering C: Materials for Biological Applications. 42: 168-176. 2014.
21. Aiyangar A., Vivanco J., Au, A., Smith E., Ploeg HL "Axial and Transverse Compressive Properties of Human Lumbar Vertebral Trabecular Bone". Journal of Biomechanical Engineering. 2014.
22. Slane J., Vivanco J., Ebenstein D., Squire M., Ploeg HL "Multiscale Characterization of Acrylic Bone Cement Modified with Functionalized Mesoporous Silica Nanoparticles". Journal of Mechanical Behavior of Biomedical Materials. 37: 141-152. 2014.
23. Slane J., Vivanco J., Meyer J., Ploeg HL, Squire M. "Modification of Acrylic Bone Cement with Mesoporous Silica Nanoparticles: Effects on Mechanical, Fatigue and Absorption Properties." Journal of Mechanical Behavior of Biomedical Materials. 29: 451-461. 2014.
24. Vivanco J., García S., Ploeg HL, Alvarez G., Cullen D., Smith E. "Apparent Elastic Modulus of Ex Vivo Trabecular Bovine Bone Increases with Dynamic Loading". Journal of Engineering in Medicine. 27 (8): 902-910. 2013.
25. Vivanco J., Aiyangar A., Araneda A., Ploeg HL, "Mechanical Characterization of Injection-Molded Macro Porous Bioceramic Bone Scaffolds". Journal of Mechanical Behavior of Biomedical Materials. 9: 137-152. 2012.
26. Vivanco J., Araneda A., Ploeg HL, "The Effect of the Sintering Temperature on Microstructural Properties of Bioceramic Bone Scaffolds". Biomaterials Science: Processing, Properties and Applications II. John Wiley & Sons, Inc. 101-109. 2012.
27. Vivanco J., Slane J., Nay R., Simpson A., Ploeg HL, "The Effect of Sintering Temperature on the Microstructure and Mechanical Properties of a Bioceramic Bone Scaffold." Journal of Mechanical Behavior of Biomedical Materials. 4: 2150-60. 2011.
28. Vivanco J., Smith B., Blake A., Ploeg HL, Turner K. "3D Elastomeric Scaffolds- Fabricated by Casting in Micro End Milled Molds." Journal of Biomimetics, Biomaterials and Tissue Engineering. 9: 17-23. 2011.
29.Vivanco J., Fang Z., Levine D., Ploeg HL “Evaluation of the Mechanical Behavior of a Direct Compression Molded Porous Tantalum-UHMWPE Construct: a Microstructural Model”. Journal of Applied Biomaterial and Biomechanics. 7: 34-42. 2009.
30.Vivanco J., Fang Z., Levine D., Ploeg HL "Microstructural Mechanical FE Analysis of Compression Molded Porous Tantalum-UHMWPE". Journal of Biomechanics. 41: S444. 2008
We have equipment at the Bioengineering Center of the Adolfo Ibáñez University (UAI-Bio Center), Viña del Mar Campus. In addition, we have access to equipment outside the University, through collaborations and external services.
MOLECULAR BIOLOGY EQUIPMENT
We have traditional thermal cyclers (Applied Biosystems and Axygen) and a real-time thermal cycler (Agilent AriaMX), a Shimadzu spectrophotometer, a BioTek 800TS plate reader, a Promega Quantus fluorimeter, nucleic acid electrophoresis equipment (CBS Scientific) and proteins ( Biorad), ultracentrifuges (Boeco and Thermofisher) and all the reagents and supplies necessary for enzymatic and molecular analyzes.
CELL CULTURE ROOM
We have a clean room (QClass), which includes all the necessary equipment, such as a BioAir model TopSafe type II biosafety cabinet, a Logos Biosystems model LUNA-II automatic cell counter, a Motic model AE2000 inverted microscope, a ELMI model CM-7S centrifuge, and a Shel Lab model 2406-2 CO2 incubator. In addition, we have stocks of adult stem cells available in nitrogen, along with all the reagents and supplies necessary to perform in vitro experiments.
MECHANICAL EXPERIMENT EQUIPMENT
We have an Electrodynamic system (Test resources 800LE3) to carry out material characterization studies, static resistance and fatigue, with a load level of + -5.7 kN, maximum speed of 125 mm / s, and a maximum frequency of 15 Hz. We also have different types of fixings and load cells for different levels of force. In addition, we have a micromechanical system (Biomomentum model mach-1 v500c) to determine micro-scale mechanical properties.
We have commercial fused deposition modeling printers as well as a printer manufactured by our research group, which is used in both research and teaching. We also have 3D bioprinting technology, such as a Cellink Inkredible + biological printer, which has various biotinks to manufacture cell-loaded structures. Finally, we have a wide range of biotinks and polymer filaments and composites that can be used to make samples in the laboratory.